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DeCS
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Descriptor English:
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Antibodies, Bispecific
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Descriptor Spanish:
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Anticuerpos Biespecíficos
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Descriptor Portuguese:
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Anticorpos Biespecíficos
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Synonyms English:
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Antibodies, Bifunctional
Antibodies, Bispecific Monoclonal
Bifunctional Antibodies
Bispecific Antibodies
Bispecific Monoclonal Antibodies
Monoclonal Antibodies, Bispecific
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Tree Number:
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D12.776.124.486.485.114.125
D12.776.124.790.651.114.134
D12.776.377.715.548.114.134
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Definition English:
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Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors. |
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Indexing Annotation English:
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do not coordinate with ANTIBODY FORMATION for /biosynthesis
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Pharmacological Action:
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Immunologic Factors
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See Related English:
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Immunotoxins
Radioimmunotherapy
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History Note English:
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94
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Allowable Qualifiers English:
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Record Number:
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31649
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Unique Identifier:
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D018033
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Occurrence in VHL:
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Similar:
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DeCS
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